Zhong-Yin Zhang Selected Research

Protein Tyrosine Phosphatases

12/2020	Therapeutic Targeting of Protein Tyrosine Phosphatases from Mycobacterium tuberculosis.
1/2019	Tyrosyl phosphorylation of KRAS stalls GTPase cycle via alteration of switch I and II conformation.
2/2018	Targeting ovarian cancer and endothelium with an allosteric PTP4A3 phosphatase inhibitor.
1/2018	Development and Characterization of an Endotoxemia Model in Zebra Fish.
11/2017	Therapeutic Targeting of Oncogenic Tyrosine Phosphatases.
10/2017	PTP4A1 promotes TGFβ signaling and fibrosis in systemic sclerosis.
10/2016	Inhibition of Low Molecular Weight Protein Tyrosine Phosphatase by an Induced-Fit Mechanism.
3/2016	Mycobacterial Protein Tyrosine Phosphatases A and B Inhibitors Augment the Bactericidal Activity of the Standard Anti-tuberculosis Regimen.
1/2016	Inhibition of SHP2 ameliorates the pathogenesis of systemic lupus erythematosus.
10/2014	Diversity-Oriented Synthesis for Novel, Selective and Drug-like Inhibitors for a Phosphatase from Mycobacterium Tuberculosis.

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Zhong-Yin Zhang Research Topics

Disease

39	Neoplasms (Cancer) 01/2022 - 04/2004
14	Obesity 01/2018 - 02/2003
10	Neoplasm Metastasis (Metastasis) 05/2014 - 01/2006
8	Autoimmune Diseases (Autoimmune Disease) 07/2021 - 12/2007
8	Carcinogenesis 01/2020 - 02/2007
5	Type 2 Diabetes Mellitus (MODY) 10/2015 - 02/2003
5	Plague (Bubonic Plague) 08/2010 - 08/2003
4	Infections 01/2022 - 11/2013
4	Breast Neoplasms (Breast Cancer) 12/2020 - 06/2006
4	Tuberculosis (Tuberculoses) 03/2016 - 03/2013
4	Leukemia 10/2015 - 01/2011
3	Ovarian Neoplasms (Ovarian Cancer) 01/2019 - 07/2011
3	Fibrosis (Cirrhosis) 01/2018 - 08/2014
3	Rheumatoid Arthritis 05/2016 - 12/2007
3	Noonan Syndrome (Female Pseudo-Turner Syndrome) 01/2016 - 01/2011
3	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 01/2015 - 02/2010
2	Inflammation (Inflammations) 01/2018 - 01/2017
2	Communicable Diseases (Infectious Diseases) 01/2017 - 03/2012
2	Neuroinflammatory Diseases 10/2016 - 04/2016
2	Systemic Lupus Erythematosus (Libman-Sacks Disease) 01/2016 - 12/2007
2	Insulin Resistance 10/2015 - 10/2012
2	Metabolic Syndrome (Dysmetabolic Syndrome X) 07/2005 - 11/2003
1	Status Epilepticus (Complex Partial Status Epilepticus) 05/2022
1	Glioblastoma (Glioblastoma Multiforme) 01/2022
1	Brain Neoplasms (Brain Tumor) 01/2022
1	Endotoxemia 01/2018
1	Colorectal Neoplasms (Colorectal Cancer) 06/2017
1	Melanoma (Melanoma, Malignant) 11/2016
1	Osteoarthritis 05/2016
1	Pneumonia (Pneumonitis) 03/2016
1	Congenital, Hereditary, and Neonatal Diseases and Abnormalities (Congenital Disorders) 01/2016
1	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 01/2016
1	Astrocytoma (Pilocytic Astrocytoma) 11/2015
1	Glioma (Gliomas) 11/2015
1	Fatty Liver 10/2015
1	Weight Loss (Weight Reduction) 01/2015
1	Glucose Intolerance 01/2015
1	Neuroblastoma 11/2014
1	Juvenile Myelomonocytic Leukemia 10/2014
1	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 10/2014
1	Disease Progression 08/2014

Drug/Important Bio-Agent (IBA)

34	Phosphoric Monoester Hydrolases (Phosphatases)IBA 01/2020 - 02/2003
18	Protein Tyrosine PhosphatasesIBA 12/2020 - 08/2003
13	Tyrosine (L-Tyrosine)FDA Link 01/2018 - 05/2007
11	Pharmaceutical PreparationsIBA 12/2020 - 11/2003
9	Non-Receptor Type 1 Protein Tyrosine PhosphataseIBA 04/2016 - 11/2003
7	Insulin (Novolin)FDA Link 01/2018 - 02/2003
6	6-pyruvoyltetrahydropterin synthase (PTPS)IBA 11/2017 - 06/2008
6	LeptinIBA 10/2015 - 02/2003
5	Proteins (Proteins, Gene)FDA Link 01/2022 - 03/2012
4	Oncogene Proteins (Oncogene Protein)IBA 02/2018 - 07/2011
4	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 11/2017 - 06/2008
4	Virulence Factors (Pathogenicity Factors)IBA 03/2016 - 08/2003
3	Paclitaxel (Taxol)FDA LinkGeneric 01/2019 - 07/2011
3	Non-Receptor Type 11 Protein Tyrosine PhosphataseIBA 01/2018 - 05/2016
3	Non-Receptor Type 2 Protein Tyrosine PhosphataseIBA 10/2016 - 01/2013
3	Glucose (Dextrose)FDA LinkGeneric 01/2015 - 10/2012
3	Phosphotransferases (Kinase)IBA 03/2014 - 06/2006
3	ErbB Receptors (EGF Receptor)IBA 10/2013 - 01/2006
2	PTEN Phosphohydrolase (PTEN Phosphatase)IBA 01/2020 - 07/2008
2	Insulin ReceptorIBA 01/2018 - 11/2003
2	Pro-Opiomelanocortin (Proopiomelanocortin)IBA 01/2018 - 01/2015
2	Small Interfering RNA (siRNA)IBA 06/2017 - 11/2013
2	CytokinesIBA 01/2016 - 01/2015
2	Biomarkers (Surrogate Marker)IBA 01/2014 - 02/2010
1	Anticonvulsants (Antiepileptic Drugs)IBA 05/2022
1	Polysaccharides (Glycans)IBA 01/2022
1	Immune Checkpoint InhibitorsIBA 01/2022
1	RE1-silencing transcription factorIBA 01/2022
1	AmylopectinIBA 01/2022
1	Non-Receptor Type 22 Protein Tyrosine PhosphataseIBA 07/2021
1	T-Cell Antigen Receptors (T-Cell Receptor)IBA 07/2021
1	TensinsIBA 01/2020
1	Focal Adhesion Protein-Tyrosine KinasesIBA 01/2019
1	ras ProteinsIBA 01/2019
1	DNA (Deoxyribonucleic Acid)IBA 12/2018
1	Etoposide (VP 16)FDA LinkGeneric 12/2018
1	Quinic Acid (Quinate)IBA 12/2018
1	LigandsIBA 12/2018
1	Drug CarriersIBA 12/2018
1	Polylactic Acid-Polyglycolic Acid CopolymerIBA 12/2018
1	SelectinsIBA 12/2018
1	Polyethylene Glycols (Polyethylene Glycol)FDA LinkGeneric 12/2018
1	JMS-053IBA 02/2018
1	EndotoxinsIBA 01/2018
1	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 11/2017
1	Bleomycin (Blenoxane)FDA LinkGeneric 10/2017
1	GSK3235025IBA 06/2017
1	PR5-LL-CM01IBA 06/2017
1	Protein-Arginine N-Methyltransferases (Methyltransferase, Protein Arginine)IBA 06/2017
1	InterferonsIBA 01/2017
1	Pyrazinamide FDA LinkGeneric 03/2016
1	Rifampin (Rifampicin)FDA LinkGeneric 03/2016
1	Isoniazid (Ftivazide)FDA LinkGeneric 03/2016
1	AgarIBA 11/2015
1	trkB ReceptorIBA 11/2014

Therapy/Procedure

17	Therapeutics 01/2022 - 02/2003
2	Immunotherapy 01/2022 - 07/2021
1	Duration of Therapy 03/2016
1	Precision Medicine 10/2015